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Thursday, August 25, 2005 Parkinson’s Disease: Can Oral Clathration Help? NG-Rx and PCA-Rx Medical Hypotheses Parkinson’s Disease: Can Oral Clathration Help? Can detoxification with oral clathration agents and other nutritional antioxidants aid persons suffering from Parkinson’s disease? The answer would appear to be that both oral clathration, which is an advancement over chelation therapy, and nutritional intervention with antioxidants, can indeed be helpful to such persons. To be sure, this information is on the cutting edge of complementary medicine. If you have Parkinson’s disease or know someone who does, you or that person should discuss the information in this report with a treating physician. Its importance, however, may be particularly relevant to prevention and for those persons with the early stages of the disease, and, possibly, if the benefits of one’s medications are waning. Parkinson’s Disease-Detoxification Background Data regarding . . . hepatic detoxification enzyme systems and the body's mechanisms of regulating them suggests the ability to efficiently detoxify and remove xenobiotics can affect these and other chronic disease processes [e.g., Parkinson’s disease], notes by DeAnn J. Liska, Ph.D., in the June 1998 issue of Alternative Medicine Review. If research into Parkinson’s disease continues at its present pace this dreaded disease may well be fully understood and largely preventable early in the 21st Century, opines Hans R. Larsen, M.Sc. Ch.E. Dr. Larsen asserts that it is now increasingly clear not only what causes Parkinson's, but also how it can be prevented and its relentless progress slowed down. Did You Know? Preventing Parkinson’s . . . Genetics vs. Environment Prevention (avoiding toxic exposures) and nutritional intervention may be extremely important for reducing the risk of Parkinson's disease, especially since it is not believed to be primarily genetically or age related. The disease probably stems from inherited susceptible genes combined with environmental influences. Thus, its onset is not by any means determined at birth. Nevertheless, a family history of the disease is important to take note of, since there may be some genetic susceptibility. Persons with family members who have contracted the disease need to be especially careful to pay attention to prevention early on in life. Even if the disease is not genetic in origin, the same environmental influences that led to its onset in one family member may also cause the disease in other family members. Neurotoxicity & Parkinson's Disease Since Parkinson's results from destruction of the dopamine-producing cells, the usual treatment for such patients is to give them L-dopa-containing drugs, along with other medications. This insight has also led researchers to focus on possible destructive influences on the L-dopa producing cells. It is probable that Parkinson’s is a multi-factorial disease with a variety of influences, both genetic and environmental, on its causation. It makes sense, then, to address all potential causes of the disease. One promising area of research into causes of the disease is its link with environmental neurotoxicity, which may be caused by oxidative stress and heavy metal poisoning.1,2 Many studies have shown that the disease attacks those persons with low levels of natural antioxidants (glutathione and superoxide dismutase) and high levels of iron in the substantia nigra areas of their brains, notes Dr. Larsen. Iron is susceptible to oxidation and may exacerbate free radical reactions that destroy dopamine-producing cells.3,4,5,6,7 Other metals, especially manganese, cadmium, copper, and mercury (from dental amalgams), have also been implicated as causative factors in the development of Parkinson’s disease.8,9,10,11,12 Exposure to aluminum and pesticides, possibly those containing mercury, has been linked to disease onset.13,14,15,16,17,18,19,20,21 Such xenobiotics may also trigger free radical reactions (i.e., oxidative processes) or damage other structural units of the nervous system. Help for Parkinson’s Patients Nutritional intervention for Parkinson's patients may yield its best results early on in the disease process or as a preventive measure, since cumulative damage may be difficult to reverse. There is only a small amount of data to evaluate when it comes to chelation therapy and Parkinson's disease. Nonetheless, complementary therapy based on an approach utilizing either chelation or oral clathration combined with specific antioxidants, is probably a better healing pathway for such patients than simply adhering to allopathic methods. We present three such clinical examples that suggest positive results:
Prescription for Healthy Living Parkinson’s Disease Complementary Treatment Protocol PCA-Rx Oral clathration with PCA-Rx from ASN™/MAXAM™ Nutraceutics™ appears to be an equally, if not more effective, method of reducing heavy metal burdens without clinical side effects of chelation therapy with medical drugs. Unlike methods of chelation, PCA-Rx does not remove essential minerals or other nutrients while providing often superior heavy metal removal. Directions: The usual dosage is one to eight sprays under tongue one or more times a day on an empty stomach; hold for one to two minutes. For best results, do not consume anything within 30 minutes of taking. Antioxidant Environmental Toxin Protection ASN™/MAXAM™ Nutraceutics™ also produces an excellent antioxidant formula known as Antioxidant Environmental Toxin Protection with recommended antioxidants, including pine bark, grape seed, and green tea, for Parkinson’s patients. Directions: Spray into mouth and hold for approximately one to two minutes before swallowing. Use five to ten sprays one or more times each day. No food or drink 30 minutes before or after use. NG-Rx NG-Rx is a neurotropic agent thought to aid neural regeneration and should be used in consultation with your treating physician as a complementary therapy. It contains acetyl l-carnitine; phosphatidyl serine; dimethylamino ethanol (DMAE); l-tyrosine and Ginkgo biloba. An experimental study reported in Life Sciences in 1982 showed that supplementation with six to seven grams of tyrosine daily increased the dopamine formation in the brain of patients with Parkinson's disease. However, the nutrient particle sizes in ASN™/MAXAM™ Nutraceutics™ products are formulated in nanometers and in a natural colloid that the body recognizes it as a nutrient. These colloidal nanometer particles are better absorbed and, thus, the dosage required for similar benefits may be less. Availability: Both PCA-Rx and Antioxidant Environmental Toxin Protection are available at natural health centers and from health professionals from ASN-MAXAM Nutraceutics. To find a natural health center or health professional in your area carrying PCA-Rx or Antioxidant Environmental Toxin Protection, call ASN-MAXAM Nutraceutics toll-free at (800) 800-9119. PCA-Rx Oral Clathration Case Histories Case #1: In one case, a mercury-exposed patient began on PCA-Rx for approximately nine days. Post-provocation results showed that with PCA-Rx mercury excretion increased 2,650 percent from .009 milligrams per kilogram (mg/kg) to .239 mg/kg. Other toxic metals that increased in the stool were arsenic, cadmium, lead, platinum, and thallium. Case #2 A 58-year-old female was known to be mercury toxic from a dimercaptopropanesulfonate challenge in June 2000. Her amalgam fillings had been removed only two months earlier. Her levels were in the very elevated’ range. In July, pre-challenge urine and stool samples were collected. The patient then took three doses of PCA-Rx the first day and another urine sample was collected the following morning. The patient was then placed on one dose per day for the following four days. On the fifth day, another urine and stoop sample was taken. PCA-Rx increased lead excretion in the stool by almost fivefold and mercury excretion, also in the stool, by two fold. Urinary excretion increased for lead, arsenic, tin, and thallium. PCA-Rx is different from chelation agents. It works on the principle of clathration. Its contingent of specifically sequenced peptides form a lattice or inclusion complex. Multiple receptor sites attach to a toxic molecule with irreversible bonds, literally wrapping around the toxic substance to prevent additional reactions with tissues or organs as it is eliminated from the body. |